Britain’s decision to withdraw from the EU has sent shockwaves throughout the international community. It will require changes in many different areas of European and British policymaking, and its impact could linger for decades. No less important will be the increasingly important use of economic sanctions by the EU and UK in the conduct of their foreign policy. Favored by both in lieu of military force and diplomatic weight, economic sanctions have played a major role in the management and resolution of a variety of conflicts and issues around the world. How will this change in Europe in light of BREXIT? Will the UK retain its role and posture as an advocate and leader of economic sanctions? How should the United States respond?